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high Adult volume group


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The investigators emphasized this latter analysis and reported this as a positive trial. Application of blood purification techniques in this setting may improve outcomes. The concept of delivering high doses of chemotherapy while avoiding systemic toxicity is attractive because malignant glioma—related deaths are nearly always the result of an inability to control intracranial disease rather than the result of distant metastases. Concern for therapy-related electrolyte abnormalities can easily be overcome by a standardized replacement protocol.


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